Atmospheric Infrared Sounder (AIRS) aboard the National Aeronautics and Space Administration (NASA) Aqua satellite has been operating since September 2002. Its information content, superb instrument performance, and dense sampling pattern make the AIRS radiances an invaluable data set for climate studies. The trends of global-mean, nadir-view, clear-sky AIRS radiances from 2003 to 2020 are studied here, together with the counterparts of synthetic radiances based on two reanalyzes, European Centre for Medium-Range Weather Forecasts Reanalysis V5 (ECMWF ERA5) and NASA Goddard Earth Observing System V5.4.1 (GEOS-5.4.1; a reanalysis product without assimilation of hyperspectral radiances such as AIRS). The AIRS observation shows statistically significant negative trends in most of its CO₂ channels, positive but non-significant trends in the channels over the window regions, and statistically significant positive trends in some of its H₂O channels. The best agreements between observed and simulated radiance trends are seen over the CO₂ tropospheric channels, while the observed and simulated trends over the CO₂ stratospheric channels are opposite. ERA5 results largely agree with the AIRS observation over the H₂O channels. The comparison in the H₂O channels helps reveal a data continuity issue in the GEOS-5.4.1. Contributions from individual variables to the radiance trends are also assessed by performing separate simulations. This study provides the first synopsis of the global-mean trend of AIRS radiances over all its thermal-IR channels.